FASL

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FASL

The role of Fas/FasL receptors in pathogenesis of inflammation of the nervous system induced by HSV-1 and 2 infection

PROJEKT MANAGER
Małgorzata Krzyżowska

IMPLEMENTATION PERIOD
01.10.2016  – 31.09.2018

GRAND AMOUNT:
984 000,00 PLN

AIM OF THE PROJECT

Previous studies showed that  there is a correlation between HSV infection and reaction of cells to Fas/FasL induced apoptotic and non-apoptotic signalling. Fas/FasL signalling can participate both in direct elimination of HSV infection, but also in a complex regulation of the local inflammatory response and mounting of the specific anti-viral response.
The aim of this project is to determine the role of Fas/FasL receptor signalling  in pathogenesis of the  inflammatory lesions occurring  during herpes simplex virus type 1 and 2 (HSV-1/2) infection of the central and peripheral nervous system. In particular, the project addresses the role of Fas/FasL signalling in direct elimination of HSV-1/2 infected cells and elimination of infiltrating inflammatory  cells. Furthermore, it also addresses the role of Fas/FasL signalling in mounting specific cytokine and chemokine microenvironment at the site of HSV-1/2 infection.’

Posted by Agata Kołacz, Posted on 10.06.2016
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