SIGNALLING

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SIGNALLING

ANAYSIS OF PROTEIN PHOSPHORYLATION AND SIGNALING

  • Determination of calcium ion fluxes
  • Analysis of expression and phosphorylation of signaling proteins
  • Analysis of intracellular localization of signaling proteins
  • Phosphoproteomics
  • Determination of protein kinases activity

NEW DRUG TESTING FOR EFFECTS ON THE IMMUNE SYSTEM

  • In vitro tests:
    • T-cells – proliferation, surface markers expression, cytokines production, morphology, cell motility
    • B-cells – proliferation, surface markers expression, morphology, cell motility
    • Dendritic cells – activation, antigen presentation, morphology, cell motility
    • Macrophages – activation, free radicals production, phagocytosis, morphology, cell motility
    • NK-cells – activation, cytokine production, cytotoxicity, morphology, cell motility
  • In vivo tests of immune responses using model antigens
    • Different models of autoimmune diseases and cancers

See also: Confocal Microscopy Laboratory, Flow Cytometry Laboratory, Isotopic Laboratory

Posted by Agata Kołacz, Posted on 27.10.2016
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