Nowadays, the bacterial drug resistance is the main problem in the treatment of infections. Over 60% of chronic infections are caused by bacteria producing biofilm, which forms a barrier making bacteria resistant to antibiotics. The ability to destroy the biofilm is one of the features desired in antibiotic therapy. In order to destroy or prevent biofilm development it is necessary to hydrolyse the polysaccharide envelope of bacterium, e.g. by bacteriophages. However, the disadvantage of phage therapy is the ability to mutate, possibility of producing high concentration of bacterial endotoxins and inability to monitor the phages in the body..
Here we present the protein which has hydrolytic properties against bacterial polysaccharides, thus preventing bacterial biofilm development and increasing the anti-bacterial activity of antibiotics. It is specific i.a. to Klebsiella pneumoniae, Staphylococcus aureus and Enterobacter cloacae.
The protein of the invention causes decomposition of biofilm, which provides elimination of bacterial drug resistance. Additionally, using protein alone is much safer and controllable than whole phage particle. The protein is active against highly resistant bacteria Klebsiella pneumoniae, Staphylococcus aureus and Enterobacter cloacae .
- Antibiotic therapy
- Compounds for sterilisation
Posted by Wrocławskie Centrum Badań EIT+, Posted on 20.05.2016