8. Spectrometric analysis of peptide glycosylation in patients suffering from uterine fibroids – a new NCN project for EIT +
The National Science Center as part of the MINIATURE 1 Program awarded another grant for a researcher from the Wrocław Research Centre EIT +. Scientific leader of the undertaking named The identification of glycosylation of endogenous peptides in physiological fluids of patients with uterine fibroids is Dr. Elżbieta Piątkowska, Head of the Masses Spectrometry Laboratory. Uterine fibroids are a condition that occurs in almost 20% of all women. Most often diagnosed in women between 35 and 45 years of age. Estrogens are very important in their formation. The project, which will be run at the Wrocław Research Centre EIT + in cooperation with the Pro-Familia Specialist Hospital in Rzeszów concerns spectrometric analysis of peptide glycosylation in patients suffering from uterine fibroids. The project will use mass spectrometry techniques that will be used to analyse protein modifications and determination of amino acid residues that change. The analysis of modifications will also be of particular significance to understand the processes leading to the emergence of disease states, because it is known that dysregulation of processes, eg glycosylation of proteins may be the cause of neoplastic changes. The result of the research will be obtaining information about the peptide glycans structure of the developing tumor and the possibility of using these peptides to develop a prognostic and diagnostic model for patients with benign uterine cancer.
Dr Elżbieta Piątkowska
Analytical biochemist specializing in biological mass spectrometry, especially in the analysis of proteins and protein complexes using structural mass spectrometry. Her experimental experience acquired during her doctoral studies and postdoc internship at the University of Manchester include both isolation of protein complexes and qualitative analysis. During her one-year stay at the Weizmann Institute, she analysed the structure of protein complexes using structural mass spectrometry. In addition, he has experience in molecular biology, genetics, genomics and bacterial proteomics of bacteria and various strains of Saccharomyces yeast. He is interested in the use of MS for detailed analysis of cancer cell sub-proteomes.
Posted by Wrocławskie Centrum Badań EIT+, Posted on 30.01.2018